9 Responses to “Low dose naltrexone (LDN), novel anti-inflammatory treatment for chronic pain”

  1. Lauren Says:

    I use LDN and it helps. Taken right before bedtime (I have to use Zolpidem to punch me into sleep and then when I awaken a few hours later Tizanidine and Gabapentin to push me back into sleep) the LDN helps me sleep more deeply at least for a few hours. I do sleep better and in turn have a little less pain and a bit of a decrease in flu like symptoms. I believe I have been taking this for 8 months and because I have battled Fibro and ME/CFS for about 40 years I KNOW the difference when something works and when it doesn’t. I noticed it helped by the second night of taking it.

  2. Robert Hess Says:

    A new patient of Dr. Sajben I started taking LDN (4.5mg 3 x a day) just a few days ago for chronic neuropathic pain throughout my body, especially along the spine. I felt some improvement in the form of reduced pain, enhanced mood, more energy and all around greater well-being after just one dose. The next day (yesterday) the difference was even more obvious. This morning I woke up for the first time in months without major soreness and malaise. Clearly, major changes are happening in my body. My hope is that these improvements will continue to build over time.

    The only side effect I am experiencing is some insomnia due to what I would describe as excess energy. I just don’t feel tired at my usual bed time (though I take a morning dose of LDN, not night time). Once I am asleep, I do not wake up nor do I have unusual dreams or other adverse experiences. Last night was already better than the first, so hopefully the insomnia will resolve over the next days or weeks.

    In any event, I am very glad I tried LDN. It may well be a game changer for me.


    • Nancy Sajben MD Says:

      For those in the LDN community who feel you must never take more than 4.5 mg, this is an example of why it is important not to be dogmatic about dosage. Sadly, some of my patients on LDN forums have felt forced to sign off because of dogma that does not relate to their experience. He had no response at 1 mg for 5 days or 2 mg for 5 days, 4.5 mg or 9 mg. It was only taking 4.5 mg x 3 that he first felt response, and this correlates with other patients I have seen. It is dose dependent.

      One Caution: with Multiple Sclerosis a low dose may be critical, only in that condition.

    • Robert Hess Says:

      Update 2/28: Last night I had no problems falling asleep nor did I have any insomnia at night. Maybe, it was because I took my morning dose at 7:00am instead of 9:00 am, i.e., two hours earlier. My sense is actually that that’s not the case. The first two days on LDN in general were almost euphoric during the day, which translated into insomnia at night. Yesterday and today, I felt and feel more normal, though still improved in the ways I described.

  3. Jimbo Says:

    I am 46 years old, 160 lbs, 6’2″, male.

    I recently started LDN for nerve related foot pain (burning underneath after walking + frequently feels cold on top).

    I started at 1.5 mg for 3 days, then 2.25 mg for 2 days and then 4.5 mg (10 days now).

    For the first few days, I slept better and also felt really good when waking up. My mood was better during the day as well. But no change in pain. When I increased to 4.5 mg, I expected / hoped for more positive changes, but after 10 days I have not noticed improvement in pain. I still sleep better, but the initial mood improvement (on lower dose) is gone.

    I am thinking that I probably went too fast and should go down to 3 mg and increase slowly from there, but I am not sure if that is the best approach.

    In your experience, what would the best approach from here to find the proper dosage?

    How long time on each dose before moving on to the next dose to try?

    How big increments?


  4. Nancy Sajben MD Says:

    I do schedule time with physicians who call from all over the world asking me to teach them what I do.

    It is not legal for an M.D. to give medical advice to patients they have not seen. If you wish an appointment, please call the office.

  5. Nancy Sajben MD Says:

    It is illegal to give medical advice without a consultation. This site is educational only. Please call for appointment.

  6. Nancy Sajben MD Says:

    FDA has approved 50 mg and higher for addiction to opioids and alcohol.

    Those are not low doses, and not used for pain and inflammation.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: