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Why taking morphine, oxycodone can sometimes make pain worse
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Article By Kelly Servick, May. 30, 2016
“Peter Grace, a neuroscientist at the University of Colorado (CU), Boulder, and his team has been trying to trace hyperalgesia to the way opioids affect the immune system.”
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“There’s an unfortunate irony for people who rely on morphine, oxycodone, and other opioid painkillers: The drug that’s supposed to offer you relief can actually make you more sensitive to pain over time. . . . A new study in rats—the first to look at the interaction between opioids and nerve injury for months after the pain-killing treatment was stopped—paints an especially grim picture. “
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“Animals given opioids become more sensitive to pain, and people already taking opioids before a surgery tend to report more pain afterward.”
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“Grace says the field badly needs a human study that systematically tests pain thresholds over time in opioid users…. In the meantime, he says, “I hope that it’ll get people to really question what the benefit of long-term opioid therapy might be.””
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© 2016 American Association for the Advancement of Science
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