Ketamine Chronic Use in Children


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Oral Ketamine for Children with Chronic Pain: A Pilot Phase 1 Study

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From 2013:

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Participants were given 14 days of oral ketamine, 3 times daily, at dosages ranging from 0.25-1.5 mg/kg/dose. Participants were assessed for toxicity and for pain severity at baseline and on day 14 of treatment

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Of these 12 children, 5 experienced improvement in their pain scores, 2 with complete resolution of pain, lasting >4 weeks off ketamine treatment.

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Ketamine for Pain in Adults and Children with Cancer: A Systematic Review and Synthesis of the Literature

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From 2013

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Neurocognitive Changes after Sustained Ketamine Administration in Children with Chronic Pain

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From 2015:

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This prospective, uncontrolled study describes the neurocognitive functioning of 11 children with chronic pain before and after 2 weeks of daily oral ketamine exposure. Neurocognitive assessment was performed at baseline, Week 2, and Week 14.

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Neurocognitive assessment was performed at baseline, Week 2, and Week 14.

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This study did not detect any decline in neurocognitive scores in a small number of children exposed to 2 weeks of oral ketamine therapy. Randomized, controlled studies of the neurocognitive effects of ketamine in children are recommended to further investigate these preliminary findings.

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Pain treatment with ketamine cannot be compared with an untreated control group, that would be inhumane. How do opioids change the brain? And how humane is it to treat severe intractable pain in children by starting opioids for the rest of their life, with monthly visits for opioid medication potentially for decades when we know opioids create pain, create inflammation, not to speak of possible addiction.

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Pain itself no doubt can create cognitive and behavioral changes. Opioids for pain and the many adjuvants may do so as well. Sleep deprivation is often an issue with untreated pain.

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For children with severe behavioral problems, violent, abusive, dangerous and frightening, how can they socialize, how make friends, and how does their brain and behavior develop with such untreated patterns as they are beginning to realize who they are, and realize how they may have permanently damaged everyone they know and love?

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And from today:

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The dark side of opioids in pain management: basic science explains clinical observation

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The Angelic face of Opium is dazzlingly seductive, but if you look on the other side of it, it will appear altogether a Devil. There is so much poison in this All-healing Medicine that we ought not to be by any means secure or confident in the frequent and familiar use of it.Thomas Willis “Medicine in Man’s Body” VII i 128 1848

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Have we all forgotten the dark side of antipsychotics given to children? What does it do to their developing brains and bodies, creating obesity and lipid disease?

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The material on this site is for informational purposes only, and is not a substitute for medical advice,

diagnosis or treatment provided by a qualified health care provider.

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Please understand that it is not legal for me to give medical advice without a consultation.

If you wish an appointment, please telephone my office.

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For My Home Page, click here:  Welcome to my Weblog on Pain Management!

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