CBD efficacy on nonmotor symptoms of Parkinson Disease anxiety & psychosis


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This is the last section of a review article Managing Psychosis in Parkinson Disease

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Results from preclinical and preliminary studies also suggest that cannabidiol (CBD) has therapeutic potential for nonmotor symptoms of PD.14 The multifaceted mechanism of action as an agonist of 5-HT1A, partial agonist of CB1 and CB2 receptors, and antagonist of the G-protein–coupled receptor GPR55 reverses the iron-induced epigenetic modification of mitochondrial DNA and the reduction of succinate dehydrogenase activity and decreases the levels of the pro-inflammatory cytokines IL-1β, TNF-α, IFN-β, IFN-γ, IL-17, and IL-6—all of which decrease pro-inflammatory mediators resulting in neuroprotective, anxiolytic, and antipsychotic effects.14

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“Several in vitro experiments have demonstrated promising neuro- protective effects of CBD in PD models. In one of these models, using PC12 and SH-SY5Y cells treated with MPP+ [1-methyl-4-phenylpyridinium], CBD increased cell viability, differentiation, and the expression of axonal [GAP-43] and synaptic [synaptophysin and synapsin I] proteins,” Ferreria-Junior and colleagues wrote,15 while acknowledging the paucity of studies that have addressed the biological bases for the purported effects of CBD on PD. “Double-blind, placebo-controlled, randomized trials with larger samples of patients with PD are needed to elucidate the possible effectiveness and mechanisms involved in the therapeutic potential of CBD in this movement disorder. This will also include the putative effects of CBD in preventing L-dopa–induced severe [adverse] effects and preventing PD progression.”

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The endocannabinoid system serves as an important filter of excitatory, inhibitory, and modulatory inputs that act at the midbrain and terminal regions to orchestrate DA neurotransmission by controlling DA cell body firing patterns, terminal release, and effects on postsynaptic sites in the striatum.16 Beneficial effects of CBD administration have been observed prior to or immediately after induction of PD-like symptoms in animal studies, which may suggest a preventive role rather than a therapeutic one.14 In an early open-label pilot study to evaluate the efficacy of CBD on nonmotor symptoms of PD in 6 patients with PDP, psychotic symptoms significantly decreased under CBD treatment, as evaluated by the brief psychiatric rating scale and the Parkinson psychosis questionnaire.17

 

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Psychiatric comorbidities prevalent in the majority of patients with PD are associated with more disease severity, impaired QOL, and increased use of healthcare resources, with longer hospital stays and re-hospitalizations adding to the total cost burden.

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Welcome to my Weblog on Pain Management!

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SCHIZOPHRENIA SIGNIFICANTLY EASED BY TALK THERAPY – LANDMARK GOVERNMENT STUDY


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FRONT PAGE NEW YORK TIMES 

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TALK THERAPY FOUND TO EASE SCHIZOPHRENIA

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 WITH 20 TO 50% FEWER DRUGS.

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 “…The findings, from by far the most rigorous trial to date conducted in the United States, concluded that schizophrenia patients who received smaller doses of antipsychotic medication and a bigger emphasis on one-on-one talk therapy and family support made greater strides in recovery over the first two years of treatment than patients who got the usual drug-focused care.”
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“….The report, to be published on Tuesday in The American Journal of Psychiatry and funded by the National Institute of Mental Health, comes as Congress debates mental health reform and as interest in the effectiveness of treatments grows amid a debate over the possible role of mental illness in mass shootings.” [that’s in blue because it’s a peaceful thought, not an active link.]

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“….Dr. Kenneth Duckworth, medical director for the National Alliance on Mental Illness, an advocacy group, called the findings “a game-changer for the field” in the way it combines multiple, individualized therapies, suited to the stage of the psychosis.”

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.J

Just announced :

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UN set to call for drug legalization, end to ‘war on drugs’ Sir Richard Branson
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….”The United Nations is on the verge of calling for governments around the world to end the “war on drugs” by decriminalizing the use and possession of illicit narcotics, according to businessman Sir Richard Branson.”

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“In a surprise post on the website of his company, Virgin, the entrepreneur and drugs campaigner said the UN Office on Drugs and Crime (UNODC) is about to announce a “refreshing shift” in direction.”
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Branson claims he broke a global media embargo to make the announcement, as the news was due to have been launched at a conference on Sunday. The Virgin chief said he feared the UN would bow to political pressure and withdraw the statement at the last minute….

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“In an as-yet unreleased statement circulated to the BBC, myself and others, the UN Office on Drugs and Crime, which has shaped much of global drug policy for decades, calls on governments around the world to decriminalize drug use and possession for personal consumption for all drugs,” Branson wrote.
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“This is a refreshing shift that could go a long way to finally end the needless criminalization of millions of drug users around the world. The UNODC document was due to be launched at the International Harm reduction conference in Malaysia yesterday.”

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“Branson went on to say that at least one government was already putting an “inordinate amount of pressure” on the UNODC over the announcement.”

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“Let us hope the UNODC, a global organization that is part of the UN and supposed to do what is right for the people of the world, does not do a remarkable volte-face at the last possible moment and bow to pressure by not going ahead with this important move,” he said.”

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“The war on drugs has done too much damage to too many people already.”

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