Cancer bone pain – cause found, drug already on market


.

.

.

 

Researchers find cause and possible relief of cancer bone pain

.

.

.

Provided by: Saint Louis University websitesearch and more info

.

 

“In a paper published in the journal Pain, Saint Louis University researcher Daniela Salvemini, Ph.D., reports discovering a key molecular pathway that drives cancer-related bone pain while providing a potential solution with a drug that already is on the market….

.

 

Metastatic pain is the single most common form of cancer pain. Cancer-induced bone pain (CIBP) is reported by 30 to 50 percent of all cancer patients and by 75 to 90 percent of late-stage patients. CIBP is driven by a combination of tumor-associated skeletal, inflammatory and neuropathic mechanisms….

.

.

In previous work, Salvemini discovered pain pathways – the molecular series of events that lead to pain – that helped researchers understand how pain occurs. One molecule that the pathways are dependent upon is called S1PR1 (sphingosine 1-phosphate receptor subtype 1). By modulating this molecule, scientists were able to block and reverse pain. This finding is particularly encouraging because a drug that modulates S1PR1 already is on the market.

.

Salvemini’s current paper reports an experiment her team conducted studying an animal model of breast cancer that has metastasized to the femur. The researchers observed in the spinal cord changes to key pathways suggesting that increases in sphingosine 1-phosphate are a key component of developing pain and that blocking this signal limits pain.

.

The research team found that targeting S1PR1 mitigates bone pain and neuroinflammation, and identifies S1PR1 as a potential therapeutic target alone or as a secondary therapy to address cancer-induced bone pain.

.

Salvemini’s notable career includes studying with a Nobel Laureate, discovering peroxynitrite, a key molecule in the development of pain and inflammation, and uncovering some of the reasons why certain chemotherapy drugs can cause patients extreme and lasting pain. Salvemini has been honored by the Academy of Science of St. Louis for her contribution to our understanding of pain with the Fellows Award, which recognizes a distinguished individual for outstanding achievement in science.

.

“Dr. Salvemini has contributed more to the eventual control of pain and opioid-induced tolerance than anyone else currently working in the field,” the Academy notes.”

..

Explore further: Researchers show that A3 adenosine receptor can activate ‘off signals’ for pain

.

More information: Shaness A. Grenald et al, Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation, PAIN (2017). DOI: 10.1097/j.pain.0000000000000965

.

.

 

.

.

.

.

.

.

.

.

.

The material on this site is for informational purposes only.

.

It is not legal for me to provide medical advice without an examination.

.

It is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.

~~

This site is not for email and not for appointments.

If you wish an appointment, please telephone the office to schedule.

~~~~~

For My Home Page, click here:  Welcome to my Weblog on Pain Management!

.

Please IGNORE THE ADS BELOW. They are not from me.

.

..

..

.

Welcome to my Weblog on Pain Management! Thanks for stopping by.


NancySajbenMDSeven years since I started this blog April 2009. It is very exciting to have this resource as a way to structure the many research publications and ideas I come across in Pain Management, Neurology, Integrative Medicine, Neuroimmunology and, yes, politics of medicine. I only wish I had had this tool decades ago so that I didn’t have to recreate the ones I’ve already reviewed and forgotten in the last 41 years, long before MRI scans and decades before computers in daily medicine. Now we all risk carpal tunnel from repetitive injury.

Chronic pain is often much more difficult to treat than cancer pain. It is tragic that < 1% of NIH budget goes for pain research, though 10 to 20% of the population in the US suffers from chronic pain, an estimated 60 million Americans, and the conditions are more prevalent among the elderly. Persons of all ages that I see tend to be more debilitated, often with anywhere from 3 to 14 different identifiable pain syndromes.

Many, including physicians, mistake pain as a symptom, failing to understand the reorganization that has occurred in the central nervous system due to neuro-plasticity; and they overlook the associated co-morbidity causing insomnia, weight gain due to medication or inactivity, depression, anxiety, spiritual and financial burdens. The lives of families and friends are diminished along with the person who has pain.

In the future, as time permits, I’ll be adding publications and articles to the site and occasionally posting with a frequency yet to be determined, hopefully twice a month.

Goals:

  • This website is dedicated to providing educational resources to patients and healthcare professionals regarding the current understanding of pain medicine, an interdisciplinary field
  • To discuss evidence-based information to improve the lives of patients who choose to use these therapies under the direction of informed physicians
  • To distinguish between harmful treatments, beneficial treatments, and treatments that can be safely integrated with conventional treatment
  • To encourage communication between patients, families and providers
  • To educate both patients and health care providers who need a more comprehensive knowledge base with current and accurate information
  • To promote ongoing professional growth through networking in a setting where treatments can be examined together to enhance lives

Please bear in mind, no information in this blog is intended to diagnose or treat any condition.

The opinions expressed here are my own, and are subject to change as new research becomes available.

.

Come with me on the High Sierra Trail

Join me on this journey……


%d bloggers like this: